Its herbal remedy is known as milk thistle extract. 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. Milk thistle is sold as an oral capsule, tablet and liquid extract. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. doi:10.1002/14651858.CD003620.pub3, Gillessen A, Schmidt HH. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Am J Gastroenterol. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. Milk thistlesupplementscontaining silymarin are commonly sold as teas or in capsule form, but are also available as tablets, soft gels, and liquid extracts. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Medically reviewed by Drugs.com on Sep 29, 2022. Some researchers have suggested milk thistle benefits when treating osteoporosis after menopause, and it's a commonly used supplement in the U.S. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Before The silymarin extracted from milk thistle is known to have antioxidant, antiviral and anti-inflammatory properties (2, 3, 4). WebMD does not provide medical advice, diagnosis or treatment. Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). However, human studies are limited and havent yet shown any beneficial effects. Depression. You should not use this product if you are allergic to milk thistle or if you have: past or present cancer of the breast, uterus, or ovary; or. JAMA. . More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. You may report side effects to FDA at 1-800-FDA-1088. Combining silybin with phosphatidylcholine and other phospholipids enhances the absorption of milk thistle's active compounds, providing powerful liver health support. Milk thistle may interact with certain medications and supplements. Milk Thistle: Generic, Uses, Side Effects, Dosages - RxList Federal government websites often end in .gov or .mil. information highlighted below and resubmit the form. If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. Would you like email updates of new search results? In this study, the effect of silibinin on A-induced anxiety/depression-like behaviors in rats was investigated. Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887, Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. According to the International OCD Foundation about half of OCD patients stop taking their medications due to negative side effects. National Center for Complementary and Integrative Health. edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. 10 Supplements You Should Be Taking After Menopause JIN_FK8R Please rate my stack I know I'm Fxxked up for now. Recent research has explored the use of milk thistle. Pain in . Historically, people have used milk thistle for liver disorders and gallbladder problems. Silybum marianum (milk thistle). Milk thistle. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. HHS Vulnerability Disclosure, Help JAMA. If youre pregnant or breastfeeding, check with your doctor before using milk thistle. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. 2014;2014:941085. doi:10.1155/2014/941085. People who have diabetes or endometriosis should check with a doctor before using milk thistle. Available for Android and iOS devices. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). 3 Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Call your doctor for medical advice about side effects. Milk thistle may not be safe for everyone. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. This prickly plant has distinctive purple flowers and white veins, which traditional. Milk Thistle: Benefits, Uses, Side Effects, and More 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. Risks. Depression and anxiety are associated with increased risk of developing AD. A double-blind controlled study. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Effects of Silybum marianum (L.) Gaertn. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. UltraThistle, the highest potency milk thistle formula, has been scientifically proven to be up to 10x more absorbable and up to 20x more effective than other standardized milk thistle formulas. Dosage and side effects. The nutritional content varies for each brand, so be sure to . There is also concern that milk thistle might affect estrogen levels. Its thought to work by making more of the milk-producing hormone prolactin. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Milk thistle is currently used for the treatment of toxin-induced liver injury, for its inhibition of progressive hepatic fibrosis and the prevention of cirrhosis, for its antifibrogenic effects in alcohol-induced cirrhosis and for modulation of insulin resistance. Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). Thank you, {{form.email}}, for signing up. official website and that any information you provide is encrypted And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. 2007;2007(4):CD003620. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. 2008;47(2):605-12. doi:10.1002/hep.22044, Fried MW, Navarro VJ, Afdhal N, et al. 2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. Clipboard, Search History, and several other advanced features are temporarily unavailable. Accessed Oct. 30, 2020. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Milk Thistle Benefits - Verywell Health Milk thistle has been shown in experimental test-tube and animal studies to stimulate bone mineralization and potentially be protective against bone loss (22, 23). Phytother Res. Its not known whether milk thistle is helpful for other conditions. It is possible to take too much, and liver toxicity has been observed in people with cancer taking silybin at very high doses (10 to 20 grams per day). The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Silibinin ameliorates anxiety/depression-like behaviors in - PubMed include protected health information. Some, but not all, milk thistle supplements are vegan. Milk thistle seems to have few side effects, even when taken for several years. Milk Thistle Benefits, Side Effects and Dosage Recommendation - Dr. Axe In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). It can help prevent elevation of liver enzymes, which can be a side effect of the medication. 2018;8:65-74. doi:10.2147/PTT.S169333. This site needs JavaScript to work properly. Milk thistle is a safe supplement that shows potential as a complementary therapy for various conditions, including liver disease, cancer and diabetes. Closer to a Cancer Cure? BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Some of the studies have been of poor quality, too. From aloe to honey, you might be surprised what basic ingredients can help improve breakouts. Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut-Brain Axis. Research on milk thistle use for specific conditions shows: Milk thistle might play a role in treating certain liver conditions. 2023 Jan 14;19:133-151. doi: 10.2147/NDT.S376380. . Milk thistle. Milk thistle is a popular herbal remedy that has been used for its therapeutic effects for centuries. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). Theres conflicting research on the benefits of milk thistle for liver health. https://www.nccih.nih.gov/health/milk-thistle. Duplication is encouraged. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. 2005 - 2023 WebMD LLC, an Internet Brands company. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. It may have protective effects on the liver, preventing damage. If you take any medicines regularly, talk to your doctor before you start using milk thistle. Depression and anxiety are associated with increased risk of developing AD. Epub 2016 Dec 22. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. Biomed Res Int. CNS Neurosci Ther. While not dangerous, it can cause scars. Wanting to take Milk Thistle and Curcumin to alleviate OCD, Depression Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Bethesda, MD 20894, Web Policies Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. 2016;68(4):1026-1073. doi:10.1124/pr.115.010843. eCollection 2022. 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971. Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). However, there are currently no human studies examining the effects of milk thistle in people with Alzheimers or other neurological conditions like dementia and Parkinsons. Beware that milk thistle can worsen depression, it doesn't act the same on everybody. In some cases it may be useful in treating these cancers, but studies have yet to fully demonstrate the safety and efficacy of milk thistle use. This publication is not copyrighted and is in the public domain. Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD Quality and active ingredients in supplements may vary widely from maker to maker. Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. We comply with the HONcode standard for trustworthy health information. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. 2023 Healthline Media LLC. 5th ed. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. For example, in one study, researchers investigated the mood elevating effects of silymarin, a collection of phytochemicals extracted from milk thistle. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. One important detoxifying ingredient is milk thistle. This herb (also known as Silybum marianum) is native to the Mediterranean region. It is primarily considered a cleansing agent and used to block or flush toxins from the body. Experts believe silymarin is the primary active ingredient of the herb. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Its main functions include antioxidant . Front Immunol. Milk thistle can cause severe allergic reaction and anaphylaxis, a rare but potentially life-threatening allergic reaction. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Not available for orders containing UltraNourish. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. More research is needed before a standard dosage of milk thistle can be recommended, so check with your healthcare provider. Silymarin: not just another antioxidant. Accessed Oct. 30, 2020. Milk thistle is a popular herbal remedy best known for its liver-protecting properties. And although milk thistle extract is commonly used as a complementary therapy for people with liver diseases, theres currently no evidence that it can prevent you from getting these conditions, especially if you have an unhealthy lifestyle. Historically, people have used milk thistle for liver disorders and gallbladder problems. What Is Complementary, Alternative, or Integrative Health? People sometimes eat the stem and leaves of milk thistle in salads. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. National Center for Complementary and Integrative Health. Milk thistle may also be used for purposes not listed in this product guide. Join 45,000+ subscribers and receive the latest, useful and exclusive health and wellness articles, health tips, special offers and more - delivered direct to your inbox. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. How Long Does It Take for Milk Thistle to Work? - LiverSupport.com Our study provides a new insight into the protective effects of silibinin in the treatment of anxiety/depression. Milk thistle has not been shown to treat or prevent cancer or reduce the side effects of cancer treatment. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Nevertheless, pregnant women, those allergic to the Asteraceae family of plants, those with diabetes and anyone with an estrogen-sensitive condition should seek medical advice before taking it. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Can Milk Thistle Help People With Diabetes? National Library of Medicine 2012;308(3):274-82. doi:10.1001/jama.2012.8265. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Milk thistle is promoted as a dietary supplement for . Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. OCD symptoms usually revolve around irrational fears, repeated thoughts, and compulsions. Do not use more of this product than is recommended on the label. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Botanicals and their bioactive phytochemicals for women's health, Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review, Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. But studies on heart benefits have only been done in people with diabetes. Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. The following list is not exhaustive. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). It is not known whether milk thistle will harm an unborn baby. Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. Milk thistle - Mayo Clinic Satisfaction. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Generic name: milk thistle [MILK-THIH-sull] Moreover, its unclear whether milk thistle is well enough absorbed in people to allow adequate amounts to pass through the blood-brain barrier. DISCUSSION: Why do I feel better with Milk Thistle? Dupuis ML, Conti F, Maselli A, et al. Do not use extra milk thistle to make up the missed dose. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. "It helps to clear out the toxins and nourish the organ," says Justice. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. However, its currently unclear if it has the same beneficial effects in humans. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Mastron JK, Siveen KS, Sethi G, Bishayee A.Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. #1: Milk thistle detoxifies the liver. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Rev Diabet Stud. Type 2 Diabetes According to research published in Phytomedicine in 2015, silymarin improved antioxidant capacity in the body and decreased inflammation in adults with type 2 diabetes by beating the placebo in a triple blind trial. ", National Center of Complementary and Alternative Medicine (NCCAM): "Milk Thistle," Herbs at a Glance: Milk thistle., Medicinenet.com: "Generic Name: Milk Thistle Oral.". Review/update the J Med Assoc Thai. By using our site, you acknowledge that you have read and understand our. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Thus, more studies are needed to determine what dose and length of treatment are needed for specific liver conditions (2, 11, 12). Hepatology. Milk Thistle Treatment for Children and Adults with - PubMed It is not known whether milk thistle passes into breast milk or if it could harm a nursing baby. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. But experts say that the evidence isnt conclusive. Accessed Oct. 30, 2020. However, there is a lack of . After using 2 tablets a day and 1 month, indigestion and pain in my liver disappeared. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. Phytomedicine. Milk Thistle: Health Benefits, Side Effects, Uses, Dose - RxList In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). This may be because people arent able to absorb enough to get a medicinal effect. Did you know that milk thistle has recently been touted as a natural remedy to help manage the debilitating symptoms of OCD? There is no standardized dosage or recommended intake for milk thistle tea, but it's generally considered safe if consumed in moderation.
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